General Information:
The Harper Cancer Research Institute (HCRI) is pleased to announce the availability of funds from the American Cancer Society Institutional Research Grant (ACS IRG) for new pilot projects. This grant provides support for beginning investigators to enable initiation of their independent research program. 

The purpose of the ACS IRG program is to attract new investigators from Notre Dame and IUSM-South Bend into cancer research and to provide support for new pilot studies that will produce preliminary data for the investigator to develop into studies that will compete successfully for external, national funds from both federal and private sources. Faculty from all disciplines, with any project relating to cancer research, are strongly encouraged to apply.

Funding: 

Funding is available for up to two pilot projects, beginning August 1, 2019, in amounts up to $30,000 (see below for eligible expenses). 

Eligibility: 

As defined by the American Cancer Society, the eligibility criteria are: 

  • All faculty with ranks of Assistant Professor, Research Professors (all ranks), or Research Scientist at Notre Dame or IUSM-South Bend are invited to apply.
  • Investigators who have NOT held or obtained a nationally competitive research grant (e.g., NIH, NSF, DOD, ACS). Applicants with prior funding from the ACS IRG or with significant funding from other sources are NOT eligible to apply (NOTE: Applicants may have funding from foundation grants as long as the grant is not the result of a national peer-reviewed competition and is for support of a different non-cancer research project).
  • Applicants that are not U.S. CITIZENS must submit proof of holding a visa that will allow the applicant to remain in the USA to complete the project. 
  • Applicants must be (or become) members of the HCRI.  Notre Dame faculty must affiliate subsequent extramural proposals with HCRI in the grant management system. 
  • Applicants who have been awarded previous funding are encouraged to check their eligibility status with Andy Bullock (sabullock@nd.edu) prior to the initiation of an application. 

Application Information and Guidelines: click here for ACS IRG Application Template

IMPORTANT: All proposals must describe new pilot studies in cancer research. All applications must present a clear plan for pursuing external funding based on the pilot project you submit to the ACS IRG.  Proposals, which exceed the page numbers or fail to follow the formatting guidelines, will be returned to the investigator without review.

  • Title page: PI information and contact information.
  • Abstract (up to 500 words), summarizing research, focus and cancer relevance.
  • Introduction to resubmission (resubmission only, one-page limit),  describing how the resubmission addresses reviewers' critiques.
  • Proposal body (six-page limit): Please use the document template, and follow standard NIH format with the below recommendations. Proposals format: Helvetica or Arial, font size 11 point or larger and 1/2 inch margins. The proposal body should include: 
  1. Background and Rationale for the pilot study 
  2. Hypothesis and Aims
  3. Research strategies: a high-level description of the research design, Methods, Data analysis/statistical plan, and alternatives. Make sure to include a description of what preliminary data to be obtained through ACS-IRG that would allow you to submit for external funding. 
  4. Potential external funding (NIH, NSF, DoD, ACS) applications: a description of how this proposal will help leverage the work for external funding. 
  5. Therapeutic Indication/Target Population /Potential Clinical Impact
  • Supporting documents (not included in the six-page limit):
  1. References Cited.
  2. Budget and Budget Justification
  3. Letters of support, independence (if relevant for a research scientist and research professor track application), and collaboration as necessary for the grant aims to be completed.
  4. Cancer Relevance Information Form
  5. Research Promotion Form

Criteria for Review:

  • Cancer relatedness.
  • Scientific merit.
  • Potential for subsequent peer-reviewed funding. 

Proposal Submission and Funding Timeline

Completed Application Due: June 15th, 2019 (5 p.m. EDT)

Funding Start Date: August  1st, 2019

Post Award Requirements: Successful applicants will be required to:

  • Provide six month and annual progress reports, including information on publications, grants, and intellectual property for a total of five years.
  • Present their research at an interactive poster session or oral presentation during the Harper Cancer Research Day. 
  • Participate in at least one service opportunity sponsored by the ACS during the year of funding.
  • Acknowledge receipt of ACS support in any presentation or publication of work funded by the ACS IRG Grant Mechanism. 
  • Click here for ACS IRG Expenditure Guidelines

 

PLEASE READ ALL INSTRUCTIONS CAREFULLY BEFORE SUBMITTING AN APPLICATION
Application Deadline and Start Date:

  • Applications are due by 11:59 p.m. EDT on June 7, 2019.

 Application Requirements:

  • Formatting 
    • Single spaced
    • Arial 11 font or larger
    • Margins 0.6" or larger
    • Assemble all sections below into a single PDF for submission

     

  • Cover Page (1page) 
    • Project Title
    • Applicant name, institution, department, position/title, email
    • Primary Mentor name, institution, department, position/title, email
    • Secondary Mentor name, institution, department, position/title, email
    • Supplemental Data (please include on cover page)         
      • Human subjects:              
        • Yes__ No__
        • Approval number_____ Approval Pending_____

         

      • Vertebrate Animals:              
        • Yes__ No__ 
        • Approval number_____ Approval pending_____ 

         

      • Applicants will:              
        • Apply for HCRI membership or are current members            Yes___ No___ 
        • Acknowledge WCF on related publications                            Yes___ No___ 
        • Designated HCRI for F&A return on related external grants  Yes___ No___ 


  • Abstract (1 page, up to 30 lines of text) 
    • Provide a succinct overview of the proposed project. Include the relevance to cancer, the broad objectives and specific aims, an overview of the research design and methods, and a brief description of the inter-disciplinary training environment. 

     

  • Research Plan (2 pages) - to be written by candidate 
    • Include background/rationale and overview of conceptual framework, experimental design, and data analysis/interpretation strategies. 
    • Include references on separate page following research plan (references not included in page limit). 

     

  • Mentorship and Training Plan (up to 2 pages) - to be written by primary and secondary mentors 
    • Describe the specific goals of the mentoring experience for this candidate, how they will be achieved, the planned contributions of the primary and secondary mentors, the interdisciplinary nature of training program and the benefits of the interdisciplinary approach. 

     

  • Primary/Secondary Mentor Information (1 page per mentor) 
    • Describe your qualifications as a mentor and your training experience. Include a Trainee Table for the last 5 years. Note to new faculty: If no prior training experience, include a narrative describing your training/mentorship approach and philosophy. 

     

  • Candidate Information (up to 2 pages) - to be written by the candidate 
    • Describe your research background and experience, your goals for this fellowship training, and overall career goals. 


  • Biographical Sketches 
    • Use NIH format. Provide Biosketches (up to 3 pages) for applicant, primary mentor and secondary mentor. Include all current and pending support. 

     

 Evaluation Criteria

  • Overall excellence of candidate 
  • Overall excellence of mentoring team 
  • Scientific excellence of project 
  • Excellence of Mentorship and Training Plan 
  • Cancer relevance of project 
  • History of or strong potential to generate data for publication 


PLEASE READ ALL INSTRUCTIONS CAREFULLY BEFORE SUBMITTING AN APPLICATION
Application Deadline and Start Date:

  • Full Applications are due by 11:59 p.m. EDT on June 21, 2019

 Application Requirements:
 

  • Formatting
  • Single spaced 
    • Arial 11 font or larger
    • Margins 0.6" or larger
    • Assemble all sections below into a single PDF for submission

     

  • Cover Page (1page) 
    • Project Title
    • Corresponding Principal Investigator name, department, position/title, email
    • Co-Investigator(s) name, institution, department, position/title, email
    • Post-doctoral Fellow name, institution, department, position/title, email (if applicable)
    • Supplemental Data (please include on cover page) 
      • Human subjects:  
        • Yes__ No__
        • Approval number_____ Approval Pending_____

         

      • Vertebrate Animals:  
        • Yes__ No__ 
        • Approval number_____ Approval pending_____ 

         

      • Applicants will:  
        • Apply for HCRI membership or are current members            Yes___ No___ 
        • Acknowledge WCF on related publications                            Yes___ No___ 
        • Designated HCRI for F&A return on related external grants  Yes___ No___  


  • Abstract (1 page, up to 30 lines of text) 
  1. Provide a succinct overview of the proposed project. Include the relevance to cancer, the broad objectives and specific aims, an overview of the research design and methods, and a brief description of the inter-disciplinary training environment. 

     

  • Research Plan 
    • Significance/Background (1 page):  
  1. relevance of proposed collaboration to a cancer-specific research problem 

 

  • Research Design (up to 3 pages), include:  
  1. overview of conceptual framework, design, methods, analyses 
  2. how the collaboration will develop novel concepts and/or approaches 
  3. how the application will generate preliminary data for an extramural application 
  4. must specify clearly defined targeted deliverables, with timeline (in at least bi-annual increments)

 

  • References (include references on separate page following research plan. References not included in page limit.)
  •  Biosketch (up to 3 pages) from each team member  

 

  • Collaboration Plan (1 pages) 
  1. Describe the inter-disciplinary team, distinct contribution and advantage of each partner to team, and inter-group communication plan 

     

  • Training/Mentoring Plan (1 page) 
    • Describe the specific mentoring and career development activities for the post-doctoral fellow and the advantages of the inter-disciplinary training opportunity. 

     

  • Budget: Provide a budget for 2 years for up to $100,000 direct costs per year as follows:  
  • (A) Post-doctoral fellow – up to $61,440 for salary and fringe benefits. 
  • Note: funds are intended to support one post-doctoral fellow to perform shared research between 2 or more labs. Partial support of 2 or more post-docs from individual collaborator labs is not intended. 
  • (B) Supplies – up to $30,000 for research supplies 
  • (C) Shared resource funding – up to $10,000 to be used only in a Notre Dame (https://research.nd.edu/our-research/facilities-and-resources/), IU or Purdue shared resource/core facility (http://www.indianactsi.org/servicecores
  • (D) Budget justification 

 

  • Progress Report 
    • A one-page progress report is due three weeks prior to the end of year 1 funding. The Progress Report must outline accomplishments during the initial funding relative to anticipated deliverables as defined in the proposal. Notice - Release of year 2 funds is contingent on meeting targeted deliverables. 


 Evaluation Criteria: Applications will be reviewed by a five member committee composed of the Institute Director and the Program Co-Leaders. Review committee members with a conflict of interest will be replaced. Subject matter experts may be brought in as warranted. The applications will be reviewed based on the criteria below.

  • Evidence of inter-disciplinary collaboration
  • Overall scientific excellence
  • Cancer relevance of project 
  • Well defined deliverables
  • Excellence of post-doctoral training plan
  • Innovation
  • Potential to generate data for competitive extra-mural application within 2 year funding period 
    • NOTE: this funding mechanism is intended to result in data of sufficient quantity and quality to support an extramural cancer-focused grant application at the end of the 2- year support period. Renewal requests for continuation of the project beyond the 2-year timeframe will not be considered. 

     


PROGRAM ANNOUNCEMENT

Across the sciences, the skills required to analyze large data sets, build statistical models, and simulate complex processes are becoming increasingly critical. For example, genomic data sets may consist of millions of sequencing reads from hundreds or thousands of samples. In ecology and earth sciences, researchers are applying new methods for modeling ecological data and assimilating data and models to improve forecasts of ecological and environmental change. In systems biology, scientists are modeling the emergent properties of interacting genes, proteins, cells, and tissues. All of these research areas depend on computational fluency. 

The REACT program (Rapid Exposure to Advanced Computational Training) is a short-term initiative to support graduate students to receive the latest training in computational tools and techniques in their field. REACT is a joint effort between the Environmental Change Initiative (ECI), the Eck Institute for Global Health (EIGH), the Genomics and Bioinformatics Core Facility (GBCF), and the Harper Cancer Institute (HCRI). REACT will provide up to $1,300 to cover student tuition, registration, and board required to attend nationally-recognized workshops that provide the latest training in computational approaches.

Eligibility

  • The applicant must be a PhD student or thesis Masters student enrolled at Notre Dame.
  • The student's advisor/PI must be a member in good standing with either the Environmental Change Initiative, the Eck Institute for Global Health, Notre Dame’s Genomics and Bioinformatics Core Facility, or the Harper Cancer Institute. Students should check with their advisors if they are not sure of their PI’s affiliations.
  • Students attending workshops may be asked to share the knowledge they gain with local working groups, journal clubs, classes, or a symposium of fellow REACT awardees.
  • REACT will cover costs for registration, tuition, room and board, up to $1,300. REACT does not cover research expenses or travel costs. Travel costs are expected to be covered by the student’s advisor/PI.

Application instructions

  1. Applications are considered on a rolling basis. All applications should be submitted online. Questions can be directed towards Beth Archie (earchie@nd.edu), Mike Pfrender (pfrender.1@nd.edu), Kathy Taylor (ktaylo12@nd.edu), or Kara Primmer (kara.huegel.2@nd.edu).
  2. Applicants will be required to:
  • Create an account with Submittable in order to submit your online application.
  • Provide information on the workshop they plan to attend.
  • Explain the computational skill(s) they will learn at the workshop and how those skills will help their research.
  • Provide information on the costs for workshop registration, tuition, and room and board. REACT provides up to $1,300 to cover these costs and these costs only.
  • Provide information on their admissions status in regards to the workshop (e.g. the student has not yet applied, the student has applied and the application is pending, or the student has applied and has been admitted to the workshop. If the latter, students will provide evidence of acceptance.)
  • Upload a short letter from the student’s sponsoring advisor/PI that states:  
  1. That the PI supports the student’s attendance at the workshop
  2. That the PI will pay for the student's travel costs
  3. Which of the following ND Centers, Initiatives, and Institutes the PI regularly affiliates with: ECI, EIGH, GBCF, or HCRI.

TME Abstract Format Requirements:

  1. Submit in a Word document only (.docx or .doc)
  2. File Name Format: PI's last name - Author's Last Name, Author's First Name
  3. Limit abstract body to 350 words
  4. 1.5 line spacing
  5. 1 inch margins
  6. Right and left justified
  7. Title font Calibri 12 bold; rest of text Calibri 11
  8. Underline poster presenter; provide department and institutional affiliations

CLICK HERE FOR EXAMPLE

Poster Blitz Session: In the Poster Blitz Session, you (or any other member of the work) will advertise your poster orally in a one minute presentation, making use of only one slide. The purpose of these sessions is to have the opportunity to give a brief overview of the content of the poster, create interest in the audience to check out your poster, and have the chance to invite them directly to visit it. Each poster blitz mini-session will occur directly before the corresponding poster session. Your slide should be similar to a graphical abstract that is commonly used in Cell Press publications.  Do not simply submit an image of your poster—these will be disqualified. We will adhere to a one slide, one-minute time limit per presentation. Please submit your slide directly to the online link provided below by Friday, May 17.

Participation in the poster blitz session is optional, but highly recommended. It is an excellent way to highlight your research and to encourage traffic to your poster immediately prior to your poster session. You also can add the experience to your CV as a selected speaking opportunity! 

Again, congratulations in your selection to present. Only a small percentage of the meeting participants were selected for these presentations. We hope you will accept this opportunity, but if for some reason you are unable to do your Poster Blitz Presentation, then please let me (laurie.littlepage@nd.edu) and Angie Cavelieri (cavalieri.2@nd.edu) know ASAP so that we can invite another speaker to do a Poster Blitz Presentation.

Grant Overview

The Harper Cancer Research Institute (HCRI) is pleased to announce the availability of travel grants to support Graduate Students and Post-Doctoral Fellows traveling to academic conferences. Each grant is worth $250.

Eligibility

  • Graduate Students and Post-Doctoral Fellows must be presenting at the conference for which they are requesting funding
  • Graduate Students and Post-Doctoral Fellows must also present their projects at HCRI Research Day
  • Graduate Students' and Post-Doctoral Fellows' participation in HCRI sponsored events will be taken into consideration when reviewing travel grant requests

Application Instructions

PLEASE READ ALL INSTRUCTIONS CAREFULLY BEFORE SUBMITTING AN APPLICATION

Application Deadline and Start Date:

  • Applications are reviewed on a rolling basis

Application Requirements:

  • Formatting
    • Single spaced
    • Arial 11 font or larger
    • Margins 0.6" or larger
    • Assemble all sections below into a single PDF for submission
  • Cover Page (1 page)
    • Conference title, date, location
    • Applicant name, institution, department, position/title, email
    • PI name, institution, department, position/title, email    
  • Conference Overview (1 page maximum) should include:
    • Provide a description of the conference and the research that the candidate (Graduate Student or Post-Doctoral Fellow) will be presenting.
  • Letter of support/recommendation from candidate’s PI
Harper Cancer Research Institute